Vitamin B3 Nicotinamide


Nicotinamide is a form of vitamin B3 that can possibly preserve and improve beta cell function. Nicotinamide is essential for growth and the conversion of foods into energy. It has been used by doctors as a diabetes treatment and prevention. Potential side effect includes headaches, Skin and GI effect, exacerbation of gout and ulcers as well as allergies. Liver and platelet function should be closely monitored while using Nicotinamide. It may increase serum concentration of the anticonvulsants and primidone.

Nicotinamide is one of the two principle form of vitamin B3 also known as Niacin. It’s an member of the b complex family which has many health benefits overall. The term Niacin is used to refer to both Nicotinamide and Nicotinic acid, which is the other principle form of the Niacin. The two forms both Nicotinamide and Nicotinic acid are similar when it comes to vitamin activity but very different when it comes to Pharmacological activity.

Nicotinamide is involved in a wide range of biological process, including the production of energy, the synthesis of fatty acids, cholesterol and steroids, signal transduction, as well as the maintenance of the integrity of the genome. Nicotinic acid in pharmacological dosage can be used as an antihyperlipidemic agent; it also causes vasodilation of cutaneous blood vessels resulting in the so called Niacin flush. Nicotinamide in pharmacological dosage does not do any of those things. However there is evidence that it may prevent type 1 diabetes mellitus. There is also evidence that it might help people with generalized granuloma annular and osteoarthritis and it may also be helpful with rheumatoid arthritis, schizophrenia or tinnitus. It has also been suggested that it might aid against certain types of cancer. Also Pyrazinamide, which is a drug that is used in the treatment of tuberculosis is an analogue of and shares the same biochemical mechanism with Nicotinamide.

Nicotinamide has also been proven to have  antioxidant benefits. It has been found to inhibit protein oxidation and lipid peroxidation. It has also been proven to inhibit reactive oxygen species-induced apoptosis, phagocytic generation of reactive oxygen species, scavenge reactive oxygen species and also to inhibit oxidative activity of nitric oxide.

As already mentioned Nicotinamide is one of the forms of vitamin B3 Niacin, which is usually used for nutritional supplementation. Nicotinamide is also the form of Niacin that is used for food fortification. It is available in both as a single ingredient product and multivitamin/ multi mineral products. Typical supplementation dosage ranges from 20 to 100 milligrams a day. Pre and postnatal vitamin and mineral supplements usually deliver a dose of 20 milligrams a day.

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